Funded Projects

The PCC has supported world-class research since 2008, spending more than $18.0 M to support novel science. Research and grant-making are the foundation of the PCC and are the focus of everyday business activity. PCC-supported research contributes to a movement in addressing doping’s root causes and ultimately decreasing the use of performance-enhancing drugs by all participants in all sports at all levels of play.

Funded PCC projects represent proposals from 14 different countries and three continents. Nearly 70 principle investigators have been awarded grants to advance anti-doping knowledge through more than 85 unique research projects. Projects which showcase alignment with the PCC research priorities are given funding precedence.

Please contact us if you have questions regarding individual projects listed here.

Fellowships

In Progress

Funded: 2014

Fellow:
Dr. Geoff Miller; Sports Medicine Research and Testing Laboratory (SMRTL)

Mentor:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)

Research Title:

Assessing hydration status through evaluation of albumin osmolality and lactate for the ABP

Publications:

American Academy of Physical Medicine and Rehabilitation: The Anti-Doping Movement
Drug Testing and Analysis: Intranasal delivery of Natesto testosterone gel and its effects on doping markers

Presentations: 

Miller G, Teramoto M, Cushman D, Eichner D. Assessing Dehydration in the Context of the
Biological Passport. 34th Cologne Workshop on Dope Analysis; Cologne, Germany. February 2016.

Nair V, Miller G, Morrison S, Summers M, Willick S, Eichner D. Intranasal Delivery of Natesto
Testosterone Gel and Its Effects on Doping Markers. 34th Cologne Workshop on Dope Analysis;
Cologne, Germany. February 2016.

Micro-Grants

In Progress

Funded: 2016

Principle Investigator:
Dr. Lena Ekstrom; Karolinska Instituet 

Pending Terms and Conditions

Funded: 2016

Principle Investigator:
Prof. Dr. Maria Kristina Parr; Freie Universitat Berlin

Pending Terms and Conditions

Funded: 2016

Principle Investigator:
Dr. Herbert Tobias; Cornell University

Pending Terms and Conditions

Principle Investigator:
Dr. Jack Henion; Q2 Solutions

Working Groups

2016 Grants

2015 Grants

Complete.

Principle Investigators:
Dr. Peter Van Eenoo; University of Ghent Doping Control Laboratory 
Dr. Michael Polet; University of Ghent

Publications:

Journal of Chromatography: Improved sensitivity by use of gas chromatography-positive chemical ionization trip quadrupole mass spectrometry for the analysis of drug related substances. 

Rapid Communications in Mass Spectrometry: Gas chromatography/chemical ionization triple quadrupole mass spectrometry analysis of anabolic steroids: ionization and collision-induced dissociation behavior.

Journal of Mass Spectrometry: Efficient approach for the detection and identification of new androgenic metabolites by applying SRM GC-CI-MS/MS: a methandienone case study.

Presentations: 

Improved sensitivity by using chemical ionization GC-MS/MS M. Polet, W. Van Gansbeke, F. Hooghe and P. Van Eenoo 33rd Cologne workshop on Dope Analysis 01/03/2015 – 06/03/2015

Chemical ionization GC-MS/MS analysis of anabolic androgenic steroids M. Polet, W. Van Gansbeke and P. Van Eenoo 34th Cologne workshop on Dope Analysis 21/02/2016 – 26/02/2016

Chemical ionization GC-MS/MS analysis of anabolic androgenic steroids M. Polet, W. Van Gansbeke and P. Van Eenoo Agilent Nordic Scientific Forum 2016 (Gothenburg) 10/03/2016 – 11/03/2016

2014 Grants


Complete.

Principle Investigator:
Dr. Kara Lynch; University of California San Francisco 

Publications:

Analytical Toxicology: Optimization and Validation of High-Resolution Mass Spectrometry Data Analysis Parameters

Clinical Chemistry: Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening

Presentations: 

Mass Spectrometry: Applications to the Clinical Lab Conference, San Diego, CA. “Broad Spectrum Screening Using Liquid Chromatography Quadrupole TOF MS: How Valuable is Retention Time for Identifying Compounds.” 03/2015

Mass Spectrometry: Applications to the Clinical Lab Conference, San Diego, CA. “Comparing TOF& QTOF for Comprehensive Drug Screening: Do You Really Need Fragmentation Information.” 03/2015

International Association of Therapeutic Drug Monitoring and Clinical Toxicology 14th International Congress, Rotterdam, Netherlands. “Optimization of data analysis parameters for clinical toxicology testing using high resolution mass spectrometry” 10/2015

Mass Spectrometry: Applications to the Clinical Laboratory Conference, Palm Springs, CA. “High Resolution Mass Spectrometry for Suspect Screening of Novel Psychoactive Substances: Is it a Viable Solution for Laboratories.” 02/2016

Mass Spectrometry: Applications to the Clinical Laboratory Conference, Palm Springs, CA. “New Library Search Algorithm Improves Identification of Drugs by LC-QqTOF” 02/2016

Yale University, Department of Laboratory Medicine, Research Conference Series. “Analytical Advances in Clinical Toxicology using High Resolution Mass Spectrometry.” 04/2016

Analytical World Conference/Society of Toxicological and Forensic Chemistry, Munich, Germany. “Q-TRAP or Q-TOF for comprehensive drug screening?” 05/2016

Complete

Principle Investigator:
Dr. Mike Ashenden; Science and Industry Against Blood doping (SIAB)

Publications:

Medicine and Science in Sports: Acute hyperhydration reduces athlete biological passport OFF-hr score

Complete

Principle Investigator:
Dr. Pauline Rudd; NIBRT

2013 Grants

Complete

Principle Investigator:
Dr. Anthony Butch; UCLA Olympic Analytical Laboratory

Presentations: 

Tu, M., Chia, D., Wei, F., Wong, D., and Butch, A. Amperometric Immunosensor for Detecting Growth Hormone Use by Athletes. 15th Annual UC Systemwide Bioengineering Symposium. June 2014, California, USA.

Complete

Principle Investigator:
Dr. Tom Brenna; Cornell University

2012 Grants

2011 Grants

2010 Grants

Complete

Principle Investigator:
Dr. Jason Dragoo; Leland Stanford Junior University

Publications: 

The American Journal of Sports Medicine: The Systemic Effects of Platelet-Rich Plasma Injection

Presentations: 

Wasterlain AS, Braun HJ, Kim HJ, Dragoo JL. “Systemic Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injection.” European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) Congress, Geneva, Switzerland. May 4, 2012.

Wasterlain AS, Braun H, Harris A, Kim HJ, Dragoo JL. “Systemic Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injection.” American Academy of Orthopaedic Surgeons (AAOS) Congress, Chicago, IL. Mar 19-23, 2013.

Wasterlain AS, Braun HJ, Kim HJ, Dragoo JL. “Systemic Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injection.” Arthroscopy Association of North America (AANA) Annual Meeting, Orlando, FL. May 19, 2012.

Wasterlain AS, Braun HJ, Kim HJ, Dragoo JL. “Effect of Platelet-Rich Plasma Injection on Systemic Concentrations of Performance-Enhancing Growth Factors.” Orthopaedic Research Society (ORS) Congress, San Francisco, CA. Feb 6, 2012.

Complete

Principle Investigator:
Dr. David Bruns; University of Virginia

Presentations:

ACLPS annual meeting; June, 2011, St. Louis, MO

USADA Science Symposium; October, 2011,  London, UK,

Pathology Research Progress Report meeting;  October, 2011, Charlottesville, VA

Circulating RNAs as markers of growth hormone doping. Presented by: BN Kelly, DM Haverstick, ML Vance, MD Thorner and DE Bruns. Growth Hormone and IGF-1 Research Society Meeting, October 2012, MUNICH

Complete

Principle Investigator: 
Dr. Nicolas Leuenberger; Swiss Laboratory for Anti-Doping Analyses

Publications: 

Analytical and Bioanalytical Chemistry: Circulating miRNAs: a new generation of anti-doping biomarkers

PLoS One: Circulating microRNAs as Biomarkers for Detection of Autologous Blood Transfusion

Advances in Experimental Medicine and Biology: Circulating microRNAs : The future of Biomarkers in Anti-doping Field 

Transfusion Medicine Reviews : Autologous Blood Transfusion in Sports : Emerging Biomarkers

Presentations: 

Circulating microRNAs to detect autologous blood transfusion. Presented by: N Leuenberger, YO Schumacher, T Pottgieser, M Saugy and S Pradervand. The Manfred Donike Workshop on Doping Analysis, February 2012, COLOGNE

Complete

Principle Investigator: 
Dr. Svetlana Appolonova; Moscow Anti-Doping Laboratory

Presentations: 

Appolonova, S. A., Mesonzhnik N.V. and Rodchenkov, G. M. (2012), Multivariate analysis in combination with electrospray ionization tandem mass spectrometry as a model for prediction of 3-ketosteroids’ and corticosteroids’ structures // Eighth Winter Symposium on Chemometrics “Modern Methods of Data Analysis”. Russia, Drakino, February 27 – March 2, 2012, P. 51-52

Mesonzhnik N.V., Appolonova, S. A., and Rodchenkov, G. M. (2012), Detecting unexpected drugs of abuse using UPLC-HRMS in combination with multivariate analysis // Eighth Winter Symposium on Chemometrics “Modern Methods of Data Analysis”. Russia, Drakino, February 27 – March 2, 2012, P. 52-53

Svetlana Appolonova, Natalia Mesonzhnik, Daria Brazhnikova and Grigory Rodchenkov. PLS-DA and OPLS-DA as a model for prediction of the steroids structures // 29th (MONTREUX) SYMPOSIUM on Liquid Chromatorgaphy/Mass Spectrometry, 7-9 November, 2012, p. 10

Svetlana Appolonova, Natalia Mesonzhnik, Daria Brazhnikova and Grigory Rodchenkov. Validation of multivariate analysis for classification of anabolic steroids and corticosteroids by MS/MS spectra // 29th (MONTREUX) SYMPOSIUM on Liquid Chromatorgaphy/Mass Spectrometry, 7-9 November, 2012, p. 11

2009 Grants

Complete

Principle Investigator: 
Dr. Peter Van Eenoo; University of Ghent Doping Control Laboratory 

Publications:

Biomedical Chromatography: In-vitro and in-vivo metabolism studies of dimethazine

Biomedical Chromatography: Metabolism of methylstenbolone studied with human liver microsomes and the uPA⁺/⁺-SCID chimeric mouse model

Presentations: 

Lootens L, Geldof L, Meuleman P, Leroux-Roels G, Deventer K, Van Eenoo P. Steroid metabolism studied via a chimeric mouse model in the framework of sports doping. 7th International Symposium Hormone and Veterinary Drug Residue Analysis. June 2014. Ghent, Belgium.

Geldof L, Lootens L, Van Lysebeth J, Meuleman P, Leroux-Roels G, Deventer K, Van Eenoo P. Metabolic study of a steroid product containing dimethazine using human liver microsomes and a chimeric mouse model. 32nd Cologne Workshop on Dope Analysis. 2014. Cologne, Germany.

Complete

Principle Investigator:
Dr. Vanessa Agon; National Measurement Institute, Australia

Presentations: 

Agon, VW., Goebel, C. Analysis of derivatised carbohydrates of natural and recombinant peptide hormones by LC/MS/MS. 29th Manfred Donike Workshop. February 2011. Cologne, Germany.

2008 Grants